“Studies on Crystallin Protein Mutations in congenital cataract”
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چکیده
In cataract the crystallin lens, the part of eye responsible for clear vision loses its transparency and the refractive index of the lens differs significantly over distances. Changes in lens cell structure, changes in lens protein constituents, or both lead to the variation in the refractive index over these distances. The lens micro-architecture gets altered which may lead to loss of vision in cataract.
منابع مشابه
Alteration of protein-protein interactions of congenital cataract crystallin mutants.
PURPOSE A recent study demonstrated the presence of protein-protein interactions among lens crystallins in a mammalian cell two-hybrid system assay and speculated about the significance of these interactions for protein solubility and lens transparency. The current study extends those findings to the following crystallin genes involved in some congenital cataracts: CRYAA (R116C), CRYAB (R120G),...
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